20 articles - From Friday Dec 06 2024 to Friday Dec 13 2024
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Am J Clin Nutr |
|---|
Plant-based meat alternatives and cardiometabolic health: A systematic review and meta-analysis. Our findings suggest substituting PBMAs for meat for up to 8 weeks lowered TC (6%), LDL-c (12%) and body weight (1%) in adults without cardiovascular diseases. PBMAs may facilitate the transition to a plant-based diet, but long-term studies are needed to evaluate their cardiometabolic effects. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
|---|
Oral Citrulline supplementation in pregnancies with preeclampsia: a multicentre, randomized, double blind clinical trial. The current trial found no benefit of oral L-citrulline supplementation to women with preeclampsia regarding either the duration of pregnancy, fetal growth, or maternal and neonatal outcome. Systolic blood pressure and liver enzymes at delivery were increased in the treated group. L-citrulline oral supplementation does not seem to be a promising candidate as a therapeutic intervention in pregnancies with preeclampsia. Clinical Trial Registration |
Prediction models of basal energy expenditure in children and adolescents across the BMI spectrum based on room-calorimetry: a cross-sectional cohort study. New BEE prediction models developed and tested in cohorts representative of children with normal weight and OW/OB had superior performance compared with existing models. The BEE prediction equations based on simple anthropometrics or body composition provided improved accuracy and precision for children with NW or OW/OB, ages 5 to 19. More accurate estimates of BEE should allow for better estimates of energy requirements of children. |
| Inflamm Bowel Dis |
Anti-integrin αvβ6 Antibodies Predict Pouchitis in Patients With Ulcerative Colitis After Restorative Proctocolectomy With Ileal Pouch-Anal Anastomosis. The anti-integrin αvβ6 antibody levels in patients with UC were decreased after RPC but remained high in patients who developed pouchitis. The antibody levels at the time of RPC may serve as a potential prognostic biomarker for predicting the risk of pouchitis in patients with UC. |
Autologous Microfragmented Adipose Tissue Injection in Refractory Complex Crohn's Perianal Fistulas: Long-Term Results at 6.7 Years Mean Follow-up. Our results show that patients who achieved closure in the first 24 weeks sustained response at long-term evaluation. In addition, there may be a rationale in repeating treatment as rescue therapy in not responding to patients. |
Dexamethasone Upregulates the Expression of the Human SLC26A3 (DRA, Down-Regulated in Adenoma) Transporter (an IBD Susceptibility Gene) in Intestinal Epithelial Cells and Attenuates Gut Inflammation. DEX treatment to mice for 7 days in the αIL-10R mAb model of colitis was able to significantly attenuate the gut inflammation and associated decrease in DRA expression. We demonstrate that DEX stimulates DRA expression via transcriptional mechanisms and suggest that upregulation of DRA may contribute to both anti-inflammatory and pro-absorptive effects of DEX. |
Estimation of the Harvey Bradshaw Index from the Patient-Reported Outcome 2 in Crohn's Disease: Results Based on a Large Scale Randomized Controlled Trial. PRO2 and HBI correlate strongly and conversion between them is possible. These findings facilitate the practical application of trial results and clinical guidelines. |
Histological, But Neither Clinical Nor Endoscopic Activity Predicts the Risk of Colectomy in Patients With Ulcerative Colitis Treated With Biologics. Severe histological activity at baseline as characterized by a higher Nancy Index or Geboes score independently predicted colectomy risk in biological-treated UC patients, whereas MES did not. Thus, histological assessment should be encouraged before initiating biological treatment. |
| J Crohns Colitis |
Modifiable psychological factors are associated with clusters of pain, fatigue, faecal incontinence and IBS-type symptoms in inflammatory bowel disease: a latent profile analysis. Recognising the potential impact of cognitive behavioural factors in exacerbating symptoms can lead to earlier identification of patients who require support and allows treatment plans to be tailored more precisely. The findings from this study promote a more integrated approach to IBD management, combining medical treatment with cognitive behavioural interventions to enhance patient care and improve outcomes. |
| Liver Transpl |
Preservation of coagulation function by normothermic machine perfusion in liver transplant as evidenced by thromboelastography parameters. Following reperfusion, there was a significant decrease in the transfusion of blood products in the NMP group compared with that in the static cold storage group. Overall, we determined that the use of intraoperative thromboelastography can provide real-time data to assess one aspect of reperfusion liver quality and viability. |
Prolonged time from cross clamp until normothermic machine perfusion start is associated with increased risk of early allograft dysfunction following DCD liver transplant. Following cross clamp, DCD liver grafts should be placed on the NMP pump as quickly as is safely and logistically possible. In cases where delays are unavoidable such as waiting for biopsy results or liver reallocation with another center, acceptable results can still be achieved and therefore livers with prolonged times should still be utilized. |
Simplified ischemia-free liver transplantation by providing alternating flow of the portal vein and hepatic artery: Applicability, efficiency, safety. The SIFLT simplifies the intricate surgical procudure while ensuring protection of livers from IRI. This technique holds promise for enabling patients to achieve clinical outcomes comparable to those of CIFLT. |
| Pancreatology |
Genotype-based prognosis prediction for MEN1-Related pancreatic neuroendocrine tumors in Korean patients a single-center retrospective study. PNETs in Korean patients with MEN1 exhibit a stable prognosis. An individualized follow-up strategy may be necessary, particularly for young patients with truncating mutation in the MEN1 gene. In addition, those with mutations in exons 3 or 10 may require more active surveillance to decrease the risk of progression. |
Repeated pancreatic juice cytology via endoscopic nasopancreatic drainage catheter combined with clinical findings improves diagnostic ability for malignant cases of suspected pancreatic cancer with non-identifiable tumors. Combining SPACE with clinical and imaging findings significantly enhances diagnostic accuracy in suspected PC cases where conventional imaging fails to detect tumors. This integrated approach has the potential to enhance clinical outcomes by facilitating more accurate patient management. |
Serum IgG4-negative and IgG4-positive type 1 autoimmune pancreatitis present with different clinicopathological features: An analysis of a nationwide survey in Japan. Patients with sIgG4-negative type 1 AIP and those with sIgG4-positive type 1 AIP present with different clinicopathological features which suggests heterogeneity of patients with type 1 AIP. Low serum IgG4 levels could indicate low disease activity in type 1 AIP. |
Plenty of the editorials are available as full text through the publisher website using the provided link
misc publications eg case reports, tools of the trade, images of the month, etc…
| J Crohns Colitis |
|---|
| Liver Transpl |
| Pancreas |
Letters to the editors and authors’ replies